Monday, November 8, 2021

Remote / Virtual Audits - Internal or Vendor Audits -  The Audit


Conduct per the Audit Plan, adjusted by any client / team feedback.

The Audit CGMP Sub-clause Matrix (ISO 13485 or 21 CFR 211, or 820, etc):

 

EU ISO 13485:2016  COMPLIANCE  AUDIT  MATRIX

 The following are ISO 13485:2016, Quality Management Systems for Medical Devices clauses (may be used as an audit checklist):

Clause                   Description                                            Reviewed (‘Y’ or ‘N’) / Comments

 

   4                        Quality Management System

                              4.1  General requirements

                              4.2  Documentation Requirements

                                              4.2.1  General

                                              4.2.2  Quality manual

                                              4.2.3  Medical device file

                                              4.2.4  Control of documents

                                              4.2.5  Control of records                                         

                            

 

    5                         Management Responsibility

                                5.1  Management commitment

5.2  Customer focus

5.3  Quality policy

5.4  Planning

                5.4.1  Quality objectives

                5.4.2  QMS planning

5.5  Responsibility, authority and communication

                5.5.1  Responsibility and authority

                5.5.2  Management responsibility

                5.5.3  Internal communication

5.6  Management review

                5.6.1  General

                5.6.2  Review input

                5.6.3  Review output

 

6              Resource Management

                6.1  Provision of resources

                6.2  Human resources

                6.3  Infrastructure

                6.4  Work environment and contamination 

                       control

                                6.4.1  Work environment

                                6.4.2  Contamination control

 

7              Product Realization

                7.1  Planning of product realization

                7.2  Customer-related processes

                                7.2.1  Determination of requirements 

                                           related to product

                                7.2.2  Review of requirements related 

                                           to product

                                7.2.3  Customer communication

 

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Subpart                 Description                                                 Reviewed (‘Y’ or ‘N’) / Comments

 

 

                7.3  Design and development

                                7.3.1  General

                                7.3.2  Design and development planning

                                7.3.3 Design and development inputs

                                7.3.4  Design and development outputs

                                7.3.5  Design and development review

                                7.3.6  Design and development verification

                                7.3.7  Design and development validation

                                7.3.8  Design and development transfer

                                7.3.9  Control of design and development 

                                          changes

                                7.3.10 Design and development files

                7.4  Purchasing

                                7.4.1  Purchasing process

                                7.4.2  Purchasing information

                                7.4.3  Verification of purchased product

                7.5  Production and service provision

                                7.5.1  Control of production and service

                                          provision

                                7.5.2  Cleanliness of product

                                7.5.3  Installation activities

                                7.5.4  Servicing activities

                                7.5.5  Particular requirements for 

                                          sterile medical devices

                                7.5.6  Validation of processes for 

                                           production / Service provision

7.5.7  Particular requirements for validation 

          of processes for sterilization and 

          sterile barrier systems

7.5.8  Identification

7.5.9  Traceability

                7.5.9.1  General

                7.5.9.2  Particular requirement for 

                              implantable medical 

                              devices

7.5.10 Customer property

7.5.11 Preservation of product

7.6  Control of monitoring and measuring 

       devices

8              Measurement, Analysis and Improvement

                8.1  General

                8.2  Monitoring and Measurement

                                8.2.1  Feedback

                                8.2.2  Complaint handling

                                8.2.3  Reporting to regulatory 

                                          authorities

                                8.2.4  Internal audit

                                8.2.5  Monitoring and measurement 

                                          of processes

                                8.2.6  Monitoring and measurement 

                                          of product

                8.3  Control of nonconforming product

                                8.3.1  General

                                8.3.2  Actions in response to

                                          non-conforming product

                                         detected after delivery

                8.4  Analysis of data

                8.5  Improvement

                                8.5.1  General

                                8.5.2  Corrective action

                                8.5.3  Preventive action     

                      

                                                                                                #  #  #

 -- jel@jelincoln.com


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